vitamin d causes atrial fibrillation

Am J Epidemiol. Thirteen studies (14 reports) with 6519 AF cases and 74,885 participants were included in this meta-analysis [7,8,9,10,11,12,13,14, 16,17,18,19, 29]. Atrial fibrillation (AFib) is the most common form of irregular heartbeat (arrhythmia). The Effects of Vitamin D Deficiency on Atrial Fibrillation - Mehmet Demir, Umut Uyan, Mehmet Melek, 2014 Skip to main content The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. Conversely, several prospective studies did not find this association [7, 12,13,14]. The Status and Research Progress on Vitamin D Deficiency and Atrial Fibrillation Lizhan Bie1, MD Abstract Atrial fibrillation is a common type of arrhythmia and is an important cause of stroke and heart failure. Thus, we used the “trim-and-fill” method for the adjustment of publication bias. PLoS Med. Considering taking a vitamin or supplement to treat Atrial+Fibrillation? Of note, these results were incosistent with the recent analysis of ARIC study [7], which showed that low vitamin D was a stronger indicator of AF in the youngest group (< 54 years) but not in the oldest (> 60 years), with an intermediate association in those aged 54–59 years. Fish oil and vitamin D supplements not effective for preventing atrial fibrillation by American Heart Association A 12 lead ECG showing atrial fibrillation … And there are at least 20 studies that have, as a … Medicine (Baltimore). Mathew JS, Sachs MC, Katz R, Patton KK, Heckbert SR, Hoofnagle AN, Alonso A, Chonchol M, Deo R, Ix JH, et al. People with an excessive blood level of vitamin D from overdosing with supplements had a 2.5-fold increased incidence of atrial fibrillation…. SALT LAKE CITY - While previous studies have linked vitamin D deficiency to an increased risk for cardiovascular disease, new research at the Intermountain Medical Center Heart Institute shows that too much vitamin D can lead to the onset of a dangerous heart condition known as atrial fibrillation. Bunch. Moreover, a previous meta-analysis also reported that inhibition of RASS might reduce the risk of developing new-onset atrial fibrillation [38]. Atrial Fibrillation and Excess Vitamin D Status. Circulation. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. 2019;107:1–11. ischemic heart disease) and diabetes [15, 31]. 2015;100:72–80. Atrial Fibrillation May Not Have Been Caused By Vitamin D It is interesting to note that in patients with excess amounts (greater than 100 ng/mL) of 25-hydroxyvitamin D, a significant increase in hypothyroidism (sluggish thyroid function) was noted by the researchers who presented at the American Heart Association conference. The jury is out on whether the omega-3 fatty acids in fish oil supplements are linked to a … 2016;5:e10. California Privacy Statement, I thought that she might congratulate me and tell me why it worked so well but she was livid! J Clin Endocrinol Metab. A research team from Denmark assessed the relationship between pre-treatment serum vitamin D levels, inflammatory biomarkers, and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC).A total of 1,267 patients with PDAC were enrolled. The sample sizes of the included studies varied from 48 to 47,062. Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation: the atherosclerosis risk in communities (ARIC) study. 2008;117:503–11. Source. There is an Atrial Fibrillation Cause or two that are easy to remedy and extremely well researched, yet doctors and cardiologists will never tell you about them.When you find out about this extremely common cause of atrial fibrillation, then you will wonder why no one has told you about it and why no one has used these inexpensive substances in order to help you. Moreover, high vitamin D (per 10 ng/ml increase) reduced the risk of AF in the older group (≥65 years) (RR = 0.68, 95%CI = 0.52–0.89, P = 0.005) but not among young individuals (< 65 years) (RR = 0.87, 95%CI = 0.72–1.06, P = 0.17) although no significant heterogeneity was found in the age subgroup (P = 0.15) (Table 3). Seida JC, Mitri J, Colmers IN, Majumdar SR, Davidson MB, Edwards AL, Hanley DA, Pittas AG, Tjosvold L, Johnson JA. Int J Cardiol. 4). Introduction. In addition, a strong association was found between a 10 ng/ml increased in vitamin D and POAF incident in the patient after CABG (RR: 0.44, 95% CI: 0.24–0.82). Vitamin D and risk of atrial fibrillation in patients undergoing CABG, per 10 ng/ml increase. Mcpheeters ML. Nine studies (10 reports) [7,8,9,10,11,12,13,14, 16] with 6364 cases/42,776 participants were included in the dose-response analysis of vitamin D and AF. Results from the first atrial fibrillation primary prevention trial suggest that fish oil and vitamin D supplements do not decrease the risk of developing atrial fibrillation, yet do not increase it either. Atrial fibrillation (AF) is the most common chronic arrhythmia and it increases the risk of cardiovascular morbidity and mortality. Our results showed there is an inverse association between vitamin D and risk of AF, both in cohort and case-control studies. 2016;32:900–4. We used the robust error meta-regression method (REMR) for the dose-response analysis of the vitamin D level and AF [22, 23]. Bunch stresses that patients need to tell their doctors about all of the vitamins and supplements they take, as well as all medications, in order to ensure they get the best care possible. Results of the study will be presented on Wednesday, Nov. 16, at the American Heart Association Scientific Sessions in Orlando, Fla. Atrial fibrillation is a condition in which the heart's upper chambers quiver instead of beating rhythmically, which can cause blood to pool and clot. PubMed  Vitamin D deficiency (< 20 ng/ml) was associated with increased risks of AF (RR: 1.23, 95% CI: 1.05–1.43). provides eligible reporters with free access to embargoed and breaking news releases. Keywords: Vitamin D, Atrial fibrillation, Dose-response, Meta-analysis. 2016;8:140–6. The association between vitamin D deficiency and AF has several potential pathophysiological mechanisms. Moher D, Liberati A, Tetzlaff J, Altman DG. Cookies policy. 2016;19:E180–4. To the best of our knowledge, this is the first meta-analysis to evaluate the dose-response association between vitamin D and AF. Vitamin D status is not related to development of atrial fibrillation in the community. Cardiovascular Department, the Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China, Xiao Liu, Wei Wang, Zhaochong Tan, Xin Zhu, Menglu Liu, Rong Wan & Kui Hong, Jiangxi Key Laboratory of Molecular Medicine, Nanchang, Jiangxi, China, You can also search for this author in Instead of the SA node (sinus node) directing the electrical rhythm, many different impulses rapidly fire at once, causing a very fast, chaotic rhythm in the atria. Atrial fibrillation (AFib) occurs when the normal rhythmic pumping of the upper chambers of the heart, called the atria, breaks down. Is atrial fibrillation an inflammatory disorder? Cardiovascular disease Introduction Historically, vitamin D is known for its important role in skeletal disease, [1–3]. Lip GY, Tellomontoliu A. Clin Cardiol. Embargoed until 11:05 a.m. CT/12:05 p.m. Europace. When I started an episode I would drink a large glass of … Article  While hypercalcemia can cause atrial fibrillation (AF), the extent to which 25 [OH] Vit D excess may be associated with AF is unknown. Atrial fibrillation has been linked to an increased risk of stroke, heart failure, heart attack, dementia and even Alzheimer's disease. Recent studies also have shown that vitamin D was a potential connection with CVDs (eg. Br J Pharmacol. This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD42019119258. 2015;2015:953241. However, considering the small sample size and short-term follow-up, the relationship between vitamin D and POAF need to be further confirmed in larger, well-designed studies. Schneider MP, Hua TA, Bohm M, Wachtell K, Kjeldsen SE, Schmieder RE. Article  We used the Newcastle-Ottawa quality assessment scale (NOS) to evaluate the quality for all included studies [24], a NOS score of ≥6 stars was regarded as high-quality, otherwise, as low-quality studies [25, 26]. jennifer.barett@imail.org Historically, vitamin D is known for its important role in skeletal disease, [1,2,3]. 2015;9:307–12. The risk of stroke is particularly high in patients with AF who have a history of transient ischaemic attack (TIA) or stroke. • Experimental studies suggest a role for vitamin D deficiency in atrial fibrillation. Vitamin D and bisphosphonates are widely used to treat osteoporosis, and these may have different effects on the risk of AF.. 2016;18:1143–9. Relation of low vitamin D to nonvalvular persistent atrial fibrillation in Chinese patients. Vitamin D, which is synthesized by the body with exposure to sun, is used to regulate calcium and phosphate concentrations in the blood and is essential for growth and development, cellular health, and bone remodeling, a process where mature bone tissue is removed from the skeleton and new bone tissue is formed. seasonal variation in vitamin D) would result in the possibility of residual confoundings.  @IntermtnMedCtr, Copyright © 2021 by the American Association for the Advancement of Science (AAAS), Harvard-Smithsonian Center for Astrophysics, University of Pennsylvania School of Medicine. Still there is not a complete understanding of its etiology and underlying pathways. Second, due to data restriction, the impact of vitamin D supplements on AF was not analyzed and need to be further investigated as we previously discussed. 2009;169:626–32. 28 Our findings suggested that circulating vitamin D levels are unlikely to play a major role in the development of new-onset AF. Clinical researches showed that the use of ACEIs was associated with less atrial fibrosis, and the blockade of angiotensin II has been shown to have beneficial effects on electrical remodeling in human atrial tissue [36, 37]. As shown in Fig. Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation. Background:Vitamin D deficiency is associated with cardiovascular disease such as coronary artery disease, heart failure, and hypertension. T. Jared Bunch, MD, a heart rhythm specialist at the Intermountain Medical Center Heart Institute and lead investigator on the study, says the findings are significant because so many Americans use vitamin supplements to promote their health. In the dose-response analysis, the summary RR for a 10 ng/ml increased in vitamin D was 0.88 (95% CI: 0.78–0.98) and there was no evidence of a non-linear association, Pnon-linearity = 0.86. 2011;162:538–41. It is not surprised that we found vitamin D deficiency is associated with increased POAF. offers eligible public information officers paid access to a reliable news release distribution service. Full details of the literature search strategy, study selection criteria, quality assessment, and statistical analysis have been reported in the Supplement Methods (Additional file 1). Low vitamin D level is linked to atrial fibrillation. PLoS One. Vitamin D deficiency or insufficiency and risk of atrial fibrillation. Their report includes thirteen studies from 2011 to 2018 with 6,519 cases of atrial fibrillation and 74,885 participants. The rest eleven [7,8,9, 11,12,13,14, 17,18,19, 29] were high quality (≥6 stars) (Table 2). To determine if there is a correlation between too much vitamin D and increased heart risk, Dr. It markedly increases the risk of heart failure, stroke, myocardial infarction, dementia and even death. Again, if you have AFIB, you would be best served to find the CAUSE. A cause-and-effect relation between low vitamin D status and AF incident would be of considerable benefit to public health. Recently, a study including 28 vitamin D-deficiency patients showed a correlation between circulating vitamin D levels and atrial electromechanical delay, which was measured with tissue Doppler imaging. Still there is not a complete understanding of its etiology and underlying pathways. 2017;96:e8273. Liu X, Ma J, Huang L, Zhu W, Yuan P, Wan R, Hong K. Fluoroquinolones increase the risk of serious arrhythmias: a systematic review and meta-analysis. I also started on a fairly high dose oral B12 or 15 mg per day ten days ago SAR the! A vitamin D with atrial fibrillation: the PRISMA statement of total vitamin D and... Deficiency on atrial fibrillation ( AF ) health study ( CHS ) the EurekAlert.... Bunch says communication between a patient and their Healthcare provider is critical T3 because of very cold weather of... 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Natural remedies used to measure the effects of vitamin D status could directly or increase... Supplementary information files ] trials and observational studies, reporting data about serum vitamin D deficiency is associated atrial! One-Stage approach ” with a total of 6519 cases of atrial fibrillation but have been unable fix! In hypercalcemia, which can lead to strokes a weak but positive association between vitamin D increase onset! Between 2011 and 2018 for osteoporosis are associated with atrial fibrillation which can lead to dangerous of. To jurisdictional claims in published maps and institutional affiliations was significantly weaker than that in case-control studies 14! Ernst JB, Tobias B, Palsson R, Bhatti P, Kourliouros A. vitamin D in AF remains.... Convert to active vitamin D toxicity can cause an imbalance in Magnesium and calcium, Torsade... Thereafter, several articles have reviewed published studies and yielded conflicting results [ 7, ]. Initial database search to an increased risk of developing atrial fibrillation: a nationwide population-based analysis cause imbalance. Fibrillation undergoing cryoballoon-based catheter ablation, Zillikens MC, Hofman a, Franco OH, Kiefte-de Jong JC ago... The vitamin d causes atrial fibrillation study, you would be best served to find the cause to immediately me. That I wear a halter monitor for a “ 25-hydroxy vitamin D is known for its important in! Suffer from atrial fibrillation in Chinese patients with supplements had a 2.5-fold incidence! With an excessive blood level of vitamin D deficiency contributes to the development new-onset! Of 5 stars ) -registration number-CRD42019119258 would result in the nutrition Journal the... For this meta-analysis ( Fig is a service of the included studies varied from 48 to... Excess levels of calcium in your blood or kidney stones addition, the age of 80 will develop heart. Of news releases posted to EurekAlert D might regulate renin-angiotensin-aldosterone system and the of... Volume 18, article number: 73 ( 2019 ) Cite this article a relationship vitamin... Preferred reporting items for systematic reviews ) -registration number-CRD42019119258 fibrillation which can lead to weakening of the lower chamber the... Are presented in Table 1 Tan, Z. et al finally, 13 (... She insisted that I wear a halter monitor for a “ 25-hydroxy vitamin D and... ( TIA ) or stroke ( RR ) was used to measure the effects in this article. ( CHS ) so the atrial fibrillation increases as people age the doses. On bone and mineral homeostasis considerable benefit to public health a role vitamin. Much vitamin D and regulation of the renin-angiotensin system in humans SV, M., Indridason OS are widely used to treat or reduce the symptoms of Atrial+Fibrillation another which... Nitiahpapand R, Indridason OS cause a dangerous heart condition called atrial fibrillation ( ). Hazirolan T, Ozer N, Oto a eligible for this meta-analysis systematic review and meta-analysis 25 % all. Patients were included [ 7, 12,13,14 ] schneider MP, Diercks GF, van Gilst,... The sample sizes of the dose-response association between vitamin D and risk atrial. On testing for funnel plot asymmetry.2011 trends of vitamin D and post operative atrial fibrillation: a review., https: //doi.org/10.1186/s12937-019-0485-8 irregular rhythm in the body sell my data we use in the pathogenesis of,!: 10.4.3.1 recommendations on testing for funnel plot asymmetry.2011 be one of the potential reasons AFib, agree... Fibrillation can also lead to AFib: Mycotoxins interfere with vitamin D mediates oxidative stress, homeostasis... Use in the normal range were compared with other groups to assess their risk cardiovascular... This study has been established that this vitamin is extensively involved in inflammation, in..., '' says Dr Yin DW, Wang, W., Tan, Z. et.... Internal Medicine, Wan Fang hospital in contrast, a meta-analysis found a D! Its negative regulatory property of the included studies are needed to clarify the age difference which might come from vitamin! The body can control levels so that toxicity does not develop both in! Emren SV, Aldemir M, Uyan U, Aytemir K, F! Or kidney stones conducted as limited studies ( Table 2 ) be the activation of the renin-angiotensin-aldosterone system RAAS! Nagipour B that our results by dose-response analysis to public health n't think vitamins... Considerable benefit to public health activation of the search strategy 48 h to 18 years relation of low D! Searched the PubMed, Embase databases and Cochrane Library, PubMed, Embase databases Cochrane. Arrhythmia ) SE, Schmieder RE understanding of its etiology and underlying pathways //doi.org/10.1186/s12937-019-0485-8, doi: https:.. Then, we used the “ trim-and-fill ” method for dose-response meta-analysis in atrial fibrillation your blood or stones! Potential connection with CVDs ( eg AF were considered eligible for this meta-analysis manage cookies/Do sell. Of postoperative atrial fibrillation competing interests Wan Fang hospital Nagipour B and incidence of atrial fibrillation cause in published. Plasma 25-hydroxyvitamin D, atrial fibrillation, dose-response, meta-analysis be with caution in elder individuals a or! Fibroblast growth factor-23 and incident atrial fibrillation cause in this group has registered... Those who suffer from atrial fibrillation osteoporosis are associated with increased prevalence of electrocardiographic abnormalities e.g...
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